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Cannabinoids (CB) are primarily liable for the physiological results of cannabis. There are over a hundred energetic compounds; cannabidiol and delta-9-tetrahydrocannabinoid (THC) are most common.Three The consequences of those compounds are mediated by way of the endocannabinoid system. As a result of CB1 receptors are positioned within the myocardium, aorta easy muscle, and vascular endothelium, it isn't shocking that acute effects of marijuana consumption embrace increases in blood pressure and coronary heart rate. Though these short-time period physiological results are properly-described, the influence of marijuana on high-danger cardiovascular outcomes such coronary atherosclerosis and myocardial infarction (MI) is much less understood. Pharmacological interactions between CB and cardiovascular therapies can happen by way of inhibition of CYP450 metabolism.5 These drug-drug interactions can cause will increase in ranges of medications together with antiarrhythmics, anticoagulants, beta-blockers, and statins.


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